Package: Certara.RsNLME
Title: Pharmacometric Modeling
Version: 3.1.1
Authors@R: c(person("James", "Craig", email = "james.craig@certara.com", role = c("aut", "cre")),
      person("Michael", "Tomashevskiy", email = "michael.tomashevskiy@certara.com", role = c("aut")),
      person("Vitalii", "Nazarov", email = "vitalii.nazarov@certara.com", role = c("aut")),
      person("Shuhua", "Hu", email = "shuhua.hu@certara.com", role = c("ctb")),
      person("Soltanshahi", "Fred", email = "fred.soltanshahi@certara.com", role = c("aut")),
      person("Certara USA, Inc.", role = c("cph","fnd"))
      )
Description: Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
    and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
    modeling. The package provides access to the same advanced Maximum Likelihood
    algorithms used by the NLME-Engine in the Phoenix platform. These tools support
    a range of analyses, from parametric methods to individual and pooled data, and
    support integrated use within the Pirana pharmacometric workbench
    <doi:10.1002/psp4.70067>. Execution is supported both locally or on
    remote machines.
Depends: R (>= 4.0)
License: LGPL-3
URL: https://certara.github.io/R-RsNLME/
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.3.2
Suggests: rlang, knitr, rmarkdown, testthat, magrittr
Imports: xml2, assertthat, Certara.NLME8 (>= 3.0.2), data.table,
        jsonlite, methods, utils, ssh
Collate: 'BootstrapParams.R' 'NlmeParallelMethod.R'
        'NlmeUserAuthentication.R' 'NlmeParallelHost.R'
        'SimpleNlmeJob.R' 'BootNlmeJob.R' 'CovariateEffectModel.R'
        'GenerateControlfile.R' 'GenerateParamsfile.R'
        'NlmeColumnMapping.r' 'NlmeCovariateParameter.r'
        'NlmeDataset.r' 'NlmeDoseMapping.R' 'NlmeEmaxParameters.R'
        'NlmeIndirectParameters.R' 'NlmeModelAbsorption.R'
        'NlmeModelParameterization.R' 'NlmeModelType.R'
        'NlmeParamsMapping.R' 'NlmePkParameters.R' 'NlmePmlModelInfo.R'
        'NlmeRandParamsMapping.R' 'NlmeRandomEffectBlock.r'
        'NlmeRemoteExecutor.R' 'NlmeScenario.R' 'NlmeTableDef.R'
        'SortColumns.R' 'ProfileParameters.R' 'ProfileNlmeJob.R'
        'ProfileVar.R' 'error_model.r' 'pml_model.r'
        'RandomEffectsMethods.R' 'ShotgunNlmeJob.R' 'SortByNlmeJob.R'
        'StepwiseParams.R' 'StepwiseNlmeJob.R' 'acceptAllEffects.R'
        'addInfusion.R' 'addLabel.R' 'addTablesToColumnMapping.R'
        'add_input_dosingCycles.R' 'bootstrap.r' 'built_in_models.r'
        'checkHostParams.R' 'colMapping.R' 'copyModel.R'
        'covariateModel.R' 'covariateNames.R' 'createInitialMapping.R'
        'create_model_from_metamodel.R' 'create_model_info.R' 'data.r'
        'dosing.r' 'editModel.R' 'emaxmodel.R' 'engine_params.r'
        'extract_mmdl.R' 'fitmodel.R' 'fitmodelHelperFunctions.R'
        'fixedEffect.R' 'generateCovarSearchArgsFile.R' 'getThetas.R'
        'get_omega_omegaSE.R' 'globals.R' 'hostParams.R' 'job.r'
        'linearmodel.R' 'log_Execution.R' 'map_covariates.R'
        'map_dosepoints.R' 'modelVariableNames.R' 'observation.r'
        'obtain_NLMELicense.R' 'parameterNames.R' 'parseControlFile.R'
        'parsePMLColMap.R' 'parse_mmdl.R' 'pkemaxmodel.R'
        'pkindirectmodel.R' 'pklinearmodel.R' 'pkmodel.R'
        'profile_estimation.r' 'randomEffect.R'
        'readInitialEstimatesParams.R' 'run_metamodel.R' 'saveModel.R'
        'saveUpdatedMetamodel.R' 'secondary_variable.r'
        'shotgunSearch.R' 'simParams.R' 'sortfit.R' 'stepwiseSearch.R'
        'structural_param.r' 'tableParams.R' 'update_PMLwithThetas.R'
        'vpc.r' 'writeColumnMapping.R' 'writeDefaultFiles.R'
NeedsCompilation: no
Packaged: 2026-03-17 21:09:34 UTC; jcraig
Author: James Craig [aut, cre],
  Michael Tomashevskiy [aut],
  Vitalii Nazarov [aut],
  Shuhua Hu [ctb],
  Soltanshahi Fred [aut],
  Certara USA, Inc. [cph, fnd]
Maintainer: James Craig <james.craig@certara.com>
Repository: CRAN
Date/Publication: 2026-03-18 06:13:33 UTC
Built: R 4.7.0; ; 2026-04-26 04:03:36 UTC; windows
